Calcineurin overexpression regulates APP metabolism
نویسندگان
چکیده
منابع مشابه
APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons
Accumulation of Aβ peptide fragments of the APP protein and neurofibrillary tangles of the microtubule-associated protein tau are the cellular hallmarks of Alzheimer's disease (AD). To investigate the relationship between APP metabolism and tau protein levels and phosphorylation, we studied human-stem-cell-derived forebrain neurons with genetic forms of AD, all of which increase the release of ...
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The ubiquitin-proteasome pathway is a major protein degradation pathway whose dysfunction is now widely accepted as a cause of neurodegenerative diseases, including Alzheimer's disease. Here we demonstrate that the F-box and leucine rich repeat protein2 (FBL2), a component of the E3 ubiquitin ligase complex, regulates amyloid precursor protein (APP) metabolism through APP ubiquitination. FBL2 o...
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ژورنال
عنوان ژورنال: Advances in Alzheimer's Disease
سال: 2013
ISSN: 2169-2459,2169-2467
DOI: 10.4236/aad.2013.23014